Enols, Enolates, and Alpha Substitution

Acidity of the Alpha Hydrogen

Kinetic vs. Thermodynamic Enolate Formation

General Mechanism of Alpha Substitution

Alpha Halogenation

The Haloform Reaction

The HVZ (Hell-Vollhard-Zelinsky) Reaction

Alpha Alkylation

Stork Enamine Synthesis

Aldol and Claisen Reactions

Introduction to Aldol Addition and Condensation

https://youtu.be/OPwpzzgpF0s

Aldol Addition/Condensation Mechanism

Mixed Aldol Condensation Reactions

Intramolecular Aldol Condensation Reactions

The Claisen Condensation Reaction

Dieckmann Condensation (Intramolecular Claisen Condensation)

Synthetic Application of Aldol and Claisen Reactions

Analyzing Claisen and Dieckmann Products for Synthesis

Beta Decarboxylation

https://youtu.be/e_8uZBNmY-4

The Malonic Ester Synthesis (of Carboxylic Acids)

The Acetoacetic Ester Synthesis (of Methyl Ketones)

The Michael Reaction (1,4 Addition to a,B-Unsaturated Carbonyl)

https://youtu.be/CE0xEtRzQYM

Robinson Annulation-An Introduction

Robinson Annulation-Complete Mechanism and Examples

Stork Enamine Synthesis (Note: Use with Michael Reaction)

https://youtu.be/YAM_LEHGHFQ